Antiretroviral Therapy for Prevention of Mother-to-Child Transmission of HIV

In 2010, new guidance from the World Health Organization (WHO) indicated that HIV-infected pregnant women in need of antiretroviral therapy (ART) for their own health--that is, women with a CD4 count ≤ 350 cells/mm3 or in WHO clinical stages 3 or 4--should receive lifelong ART. In addition, HIV-infected pregnant women not in need of treatment for their own health should receive antiretroviral (ARV) prophylaxis to prevent mother-to-child transmission (PMTCT) during pregnancy, delivery, and breastfeeding. (See the updated 2010 WHO guidelines on ARVs for PMTCT for more details on strategies and regimens for ART and ARV proplylactic use during pregnancy and breastfeeding.)

The reality, however, is that very few women receive ART in the context of PMTCT services. In addition to challenges of determining ART eligibility for HIV-infected pregnant women, several health system and social factors contribute to low uptake of ART.

PMTCT sites often do not have the capacity to initiate ART onsite. Instead, women are referred to another location, which may require another visit to the health care site. In resource-limited settings, where transportation to health care facilities can be quite difficult, women may be less likely to return for initiation of ART. Additionally, due to stigma, pregnant women may be reluctant to be seen in the same waiting area with HIV/AIDS patients or adhere to the treatment regimen itself.

As postpartum family planning counseling and provision plays a key role in PMTCT, efforts need to be made to counsel women who wish to delay or space pregnancies in the postpartum period with accurate information with regard to their family planning choices, particularly in light of the client’s ARV regimen. Healthcare providers should be provided with regularly updated technical information on family planning and ARV provision.

2010 | World Health Organization [WHO] | 116 p
    Significant progress is being made in the global scale-up of prevention of mother-to-child transmission of HIV (PMTCT), including in high burden and resource-limited settings. To continue forward with the elimination of mother-to-child transmission of HIV (MTCT), it is critically important to provide the best evidence-based interventions to reduce the risk of transmission from an HIV-infected mother to her newborn child, while at the same time promoting the health of both the mother and the child.
    2009 | Eunice Kennedy Shriver National Institute of Child Health and Human Development
    This presentation was given at Expert Panel on Prevention of Mother-to-Child Transmission of HIV given through PEPFAR (U.S. President's Emergency Plan for AIDS Relief). Presentation points out that because of a cascade effect, significantly increasing the coverage of existing treatment delivery systems by ensuring that women who attend an antenatal clinic also receive HIV testing and antiretroviral treatment could be as, or more effective than use of better PMTCT regimens. Dr.
    2007 | ACQUIRE Project/EngenderHealth | 50 p
    This document was developed for three main purposes: a) to stimulate critical thinking regarding programmatic gaps related to the reproductive health needs of women and couples living with HIV; b) to examine the HIV assessment, prevention, and referral needs of family planning (FP) clients; and c) to assist community and facility-based reproductive health (RH) providers and supervisors in tailoring services to reflect the integration needs of the communities they serve.
    2007 | World Health Organization [WHO] | 128 p
    These are interim guidelines released for country adaptation and use to help with the emergency scale-up of HIV prevention, care and antiretroviral therapy (ART) in resource limited settings. These interim guidelines are revised periodically to reflect implementation experience and new data.