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This document reviews the medical eligibility criteria for use of contraception, offering guidance on the safety of different methods for women and men with specific characteristics or known medical conditions. The recommendations are based on systematic reviews of clinical and epidemiological research. Medical Eligibility Criteria for Contraceptive Use is a companion guideline to Selected Practice Recommendations for Contraceptive Use. Together, these documents are intended to be used by policy makers, program managers, and the scientific community to support national programs in the preparation of service delivery guidelines.