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The Guidelines for Managing the HIV/AIDS Supply Chain is a set of references for managers working to ensure a continuous supply of quality HIV/AIDS commodities to programs. The Guidelines highlight lessons learned from JSI and DELIVER advisors’ experience designing, implementing, and improving HIV/AIDS supply chains in resource poor settings. The recommendations and tools presented in the Guidelines have been developed specifically for programs where supply chain implementation is occurring within the context described above. The authors recognize that as HIV/AIDS programs continue to evolve, so will supply chain solutions. The Guidelines will be updated accordingly.